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The group receiving the supplements experienced greater improvement compared to the placebo group

Because of the slow onset of action of DMARDs, corticosteroids & NSAIDs are often more heavily used as adjunct drugs during the early phase of RA treatment before the full effect of a DMARD is achieved

Betaine can increase the expression of fibroblast growth factor 21 in the liver (Reference Zeisel38) , thereby enhancing the oxidation of fatty acids

Indirect calorimetry To assess possible changes in metabolic parameters, mice were measured by indirect calorimetry using an open respirometry system (TSE PhenoMaster, TSE Systems)

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